The effects of subthalamic nucleus stimulation on semantic and syntactic performance in spontaneous language production in people with Parkinson's disease
نویسندگان
چکیده
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an established therapeutic option for advanced Parkinson's disease (PD). In this study, the effects of unilateral and bilateral STN stimulation on spontaneous language production are explored, by comparing linguistic performance in different stimulation conditions with normative data of healthy subjects. Language samples of ten PD patients with DBS of the STN were obtained in four stimulation conditions: bilateral stimulation on, bilateral stimulation off, stimulation of the left STN only and stimulation of the right STN only. The spontaneous language production differed from the normative data in all four stimulation conditions. Especially morphosyntactic elements of spontaneous language production were altered. Despite these linguistic ax: þ32 9 332 49 71.
منابع مشابه
Subthalamic nucleus stimulation and spontaneous language production in Parkinson's disease: A double laterality problem.
BACKGROUND Asymmetric degeneration of dopaminergic neurons, are characteristic for Parkinson's disease (PD). Despite the lateralized representation of language, the correlation of asymmetric degeneration of nigrostriatal networks in PD with language performance has scarcely been examined. OBJECTIVE/HYPOTHESIS The laterality of dopamine depletion influences language deficits in PD and thus mod...
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